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Posts tagged ‘RRM2’

The RRM2 mutant C198S was expressed and purified

Posted: 22.02.2016

Second mutant RRM2 construct was expressed and purified. The NMR studies of role of second cysteine in RRM2 will be performed.


The RRM2 mutant C244S was expressed and purified

Posted: 01.09.2015

This RRM2 mutant lacks cysteine that is presumably oxidized when wild-type RRM2 is treated by hydrogen peroxide. Experiment on this protein will help to understand the role of C244.


First protein expressed in newly established laboratory: RRM2

Posted: 20.01.2015


Here is the gel with analysis of differential expression of RRM2 domain from neuropathological protein TDP-43. On the last lane we observed strong band corresponding to molecular weight of about 10 kDa. Further studies of RRM2 including H/D exchange NMR experiments on 15N-labeled samples will be carried out.


RRM2 1H, 13C, 15N chemical shifts

Posted: 11.06.2014

On May 2, 2014 in repository Biological Magnetic Resonance Data Bank the assignments of 1H, 13C and 15N chemical shifts for RRM2 domain of TDP-43 protein was published.

Authors: Rabdano, Sevastyan; Podkorytov, Ivan; Yuwen, Tairan; Groves, Adam; Chamberlain, Kyle; Yakimov, Alexander; Skrynnikov, Nikolai.

BMRB 19922

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