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The Role of Rotational Motion in Diffusion NMR Experiments on Supramolecular Assemblies: Application to Sup35NM Fibrils

Posted: 23.04.2021

Dr. Boris B. Kharkov, Ivan S. Podkorytov, Dr. Stanislav A. Bondarev, Dr. Mikhail V. Belousov, Vladislav A. Salikov, Prof. Dr. Galina A. Zhouravleva, Prof. Dr. Nikolai R. Skrynnikov

https://doi.org/10.1002/anie.202102408

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Histone H4 tails in nucleosomes: a fuzzy interaction with DNA

Posted: 24.02.2021

Sevastyan O. Rabdano, Matthew D. Shannon, Sergei A. Izmailov, Nicole Gonzalez Salguero, Mohamad Zandian, Rudra N. Purusottam, Michael G. Poirier, Nikolai R. Skrynnikov and Christopher P. Jaroniec

https://doi.org/10.1002/anie.202012046

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Crystal structure of the SH3 domain of growth factor receptor-bound protein 2

Posted: 29.05.2020

Bolgov, A., Korban, S., Luzik, D., Zhemkov, V., Kim, M., Rogacheva, O., & Bezprozvanny, I. Crystal structure of the SH3 domain of growth factor receptor-bound protein 2. Acta Crystallographica Section F: Structural Biology Communications, 76(6), 263-270, 2020.

This study presents the crystal structure of the N-terminal SH3 (SH3N) domain of growth factor receptor-bound protein 2 (Grb2) at 2.5 Å resolution. Grb2 is a small (215-amino-acid) adaptor protein that is widely expressed and involved in signal transduction/cell communication. The crystal structure of full-length Grb2 has previously been reported (PDB entry 1gri). The structure of the isolated SH3N domain is consistent with the full-length structure. The structure of the isolated SH3N domain was solved at a higher resolution (2.5 Å compared with 3.1 Å for the previously deposited structure) and made it possible to resolve some of the loops that were missing in the full-length structure. In addition, interactions between the carboxy-terminal region of the SH3N domain and the Sos1-binding sites were observed in the structure of the isolated domain. Analysis of these interactions provided new information about the ligand-binding properties of the SH3N domain of Grb2.

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Structural and dynamic origins of ESR lineshapes in spin-labeled GB1 domain: the insights from spin dynamics simulations based on long MD trajectories

Posted: 20.01.2020

Izmailov, S.A, Rabdano, S.O., Hasanbasri, Z., Podkorytov, I.S., Saxena, S., Skrynnikov, N.R. Structural and dynamic origins of ESR lineshapes in spin-labeled GB1 domain: the insights from spin dynamics simulations based on long MD trajectories. Scientific Reports 2020.

DOI: 10.1038/s41598-019-56750-y

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Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2

Posted: 26.12.2019

Luzik, D.A., Rogacheva, O.N., Izmailov, S.A., Indeykina, M.I., Kononikhin, A.S., Skrynnikov, N.R. Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2. Scientific Reports 2019.

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Joint 12-th EBSA 10-th ICBP-IUPAP Biophysics Congress, Madrid, Spain

Posted: 20.07.2019

Sevastyan Rabdano took part in the biophysical congress of European Biophysical Societies Association with the oral talk “Histones in nucleosome: fuzzy interaction with DNA”. The conference was held on July 20-24, 2019 in Madrid.

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Luminescent Complexes of the Trinuclear Silver(I) and Copper(I) Pyrazolates Supported with Bis(diphenylphosphino)methane

Posted: 19.06.2019

Titov, A. A., Filippov, O. A., Smol’yakov, A. F., Godovikov, I. A., Shakirova, J. R., Tunik, S. P., Podkorytov, I. S. & Shubina, E. S. Luminescent Complexes of the Trinuclear Silver(I) and Copper(I) Pyrazolates Supported with Bis(diphenylphosphino)methane. Inorg. Chem. 58, 8645–8656 (2019).

DOI: 10.1021/acs.inorgchem.9b00991

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16th International School-Conference “Magnetic resonance and its applications, Spinus”, St. Petersburg

Posted: 31.03.2019

Nikolai Skrynnikov, Sergey Dvinskikh and Vladislav Salikov took part in the 16th international school-conference Spinus 2019, which was held March 31 – April 5, 2019 in Repino.

Nikolai Skrynnikov presented the lecture “When Molecular Dynamics met NMR (and various other experimental methods)”.

Sergey Dvinskikh presented the report “Multinuclear dipolar NMR spectroscopy in ionic liquid crystals”.

Vladislav Salikov presented the report “Protein unfolding (denaturation) as monitored by PFG NMR measurements of translational diffusion”.

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Multiplet-Matched Filtering of 103Rh Signal Using Information Contained in 31P Spectrum of AA´xXX´x 31P–103Rh Spin System

Posted: 10.10.2018

Podkorytov, I. S., Cherkasova, T. G., Kayfadzhyan, E. A. & Varshavsky, Yu. S. Multiplet-Matched Filtering of 103Rh Signal Using Information Contained in 31P Spectrum of AA′XX′ 31P–103Rh Spin System. Appl Magn Reson 50, 563–568 (2019).

DOI: 10.1007/s00723-018-1083-1

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13C NMR spectrum of crystalline [Rh(Acac) (CO)2]: A contribution to the discussion on [Rh(Acac) (CO)2] molecular structure in the solid state

Posted: 11.08.2018

Varshavsky, Yu. S., Cherkasova, T. G., Galding, M. R., Korlyukov, A. A., Podkorytov, I. S., Gindin, V. A., Smirnov, S. N., Mazur, A. S. & Rubaylo, A. I. 13C NMR spectrum of crystalline [Rh(Acac) (CO)2]: A contribution to the discussion on [Rh(Acac) (CO)2] molecular structure in the solid state. Journal of Organometallic Chemistry 874, 70–73 (2018).

DOI: 10.1016/j.jorganchem.2018.08.009

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